Eplic

Description

Product Information

• Product Name: Eplic Syrup 120ML
• Generic Name: Carbamazepine
• Strength: Carbamazepine 100mg/5ml
• Dosage Form: Oral Suspension
• Pack Size: 120ml
• Medicine Category: Anticonvulsant / Antiepileptic
• Company: Cell Laboratories Pvt Ltd.
• Prescription Status: Prescription medicine
• Price: PKR 195

Composition of Eplic Syrup 120ML

Each 5ml of Eplic Syrup 120ML contains:

• Carbamazepine 100mg

Because Eplic Syrup 120ML is an oral suspension, the bottle should be shaken well before each dose so the medicine is distributed evenly. Carbamazepine oral suspension should be measured using an appropriate calibrated medicine-measuring device rather than an ordinary household spoon. Reference prescribing information also recommends taking carbamazepine suspension with meals.

What is Eplic Syrup 120ML?

Eplic Syrup 120ML is an antiepileptic medicine containing Carbamazepine. It is used to control selected seizure disorders by reducing abnormal electrical activity in the brain.

Carbamazepine is also a specific treatment for the nerve pain caused by true trigeminal neuralgia. Clinical evidence supports its use for partial seizures, generalized tonic-clonic seizures, mixed seizure patterns that include these seizure types, and trigeminal neuralgia.

Eplic Syrup 120ML is not a simple painkiller and should not be used for ordinary headaches, body aches, dental pain, or routine nerve discomfort without medical diagnosis.

Uses & Benefits of Eplic Syrup 120ML

Eplic Syrup 120ML may be prescribed for selected neurological conditions, including:

• Partial or focal seizures
• Complex partial seizures
• Generalized tonic-clonic seizures
• Certain mixed seizure patterns
• Epilepsy requiring Carbamazepine treatment
• Pain caused by true trigeminal neuralgia
• Glossopharyngeal neuralgia in selected cases under specialist supervision

For epilepsy, Eplic Syrup 120ML may be prescribed alone or in combination with other antiepileptic medicines depending on the patient’s diagnosis and treatment response.

Is Eplic Syrup 120ML suitable for every type of seizure?

No. Carbamazepine does not adequately control absence seizures, and it should be used cautiously in certain mixed seizure disorders because seizure frequency may worsen in some patients. Therefore, the exact seizure type should be diagnosed before Eplic Syrup 120ML is prescribed.

Use in bipolar disorder

Carbamazepine is also used by specialists in some patients with bipolar disorder, particularly manic episodes. However, this use depends on the individual patient, locally approved indications, previous treatment response, and specialist judgment. Eplic Syrup 120ML should not be self-started for mood symptoms.

Who Should Use This?

Eplic Syrup 120ML may be prescribed for children or adults with a confirmed diagnosis of an appropriate seizure disorder or for patients with trigeminal neuralgia.

It may be considered for:

• Children with physician-diagnosed epilepsy
• Adults with partial or generalized tonic-clonic seizures
• Patients requiring a liquid Carbamazepine formulation
• Patients with true trigeminal neuralgia
• Patients requiring long-term antiepileptic treatment under neurological supervision
• Selected patients requiring Carbamazepine for another specialist-diagnosed condition

Children require particularly careful weight- and age-based dosing. Never give Eplic Syrup 120ML to a child using another patient’s prescription.

How to Use / Dosage

Eplic Syrup 120ML must be used exactly as prescribed by the physician. Carbamazepine dosage is individualized according to age, weight, seizure type, clinical response, blood levels, and other medicines.

General reference dosing for Carbamazepine 100mg/5ml oral suspension includes:

• Adults and children over 12 years with epilepsy: treatment may be initiated at a total of 400mg/day in divided doses and increased gradually when required.
• Children aged 6–12 years: reference treatment may begin at 200mg/day in divided doses, followed by gradual physician-directed adjustment.
• Children under 6 years: dosing is weight-based, commonly beginning at 10–20mg/kg/day in divided doses.
• Trigeminal neuralgia: reference treatment may begin at 200mg/day, followed by gradual adjustment to the lowest effective dose.

These are reference prescribing ranges, not a personal dosage recommendation. The doctor should determine the exact millilitres, frequency, dose increases, and maintenance dose for each patient.

Important administration instructions

• Shake Eplic Syrup 120ML well before each dose.
• Measure each dose accurately with a medicine syringe, cup, or other calibrated device.
• Carbamazepine suspension is generally taken with meals.
• Take doses at the times specified by the doctor.
• Do not change the dose yourself.
• Do not switch between Carbamazepine tablets and oral suspension without medical advice because dosing frequency may need adjustment.
• Do not stop Eplic Syrup 120ML suddenly.

Abrupt withdrawal of Carbamazepine can cause increased seizures and potentially life-threatening status epilepticus. Antiepileptic treatment should therefore be reduced only under medical supervision.

Price in Pakistan

Price in Pakistan: PKR 195

The listed price is for Eplic Syrup 120ML. Final retail pricing may vary according to the pharmacy, location, and available stock in Pakistan.

Precautions & Side Effects

Eplic Syrup 120ML requires medical monitoring because Carbamazepine can cause important drug interactions and, rarely, serious adverse reactions.

Before starting treatment, tell the physician if the patient has:

• Liver disease
• Kidney problems
• Previous bone-marrow or blood disorders
• Heart conduction problems
• Low sodium levels
• Glaucoma or increased eye pressure
• A history of serious medicine-related skin reactions
• Hepatic porphyria
• Pregnancy or plans to become pregnant
• Other antiepileptic, psychiatric, antibiotic, antifungal, or cardiovascular medicines

Baseline and periodic blood counts and liver-function tests may be required during treatment. Carbamazepine blood-level monitoring can also be useful in certain patients.

Important skin-reaction warning

Carbamazepine can rarely cause serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Certain HLA genetic variants are associated with increased risk, particularly in some Asian populations. Screening for HLA-B*1502 is recommended before treatment in patients with ancestry from populations in which this variant may occur.

Because Pakistan is in South Asia, this issue is particularly relevant to discuss with the prescribing doctor before a patient starts Carbamazepine.

Seek immediate medical advice if a patient taking Eplic Syrup 120ML develops a new rash, blistering, peeling skin, mouth sores, or facial swelling.

Blood-related warning

Rare cases of aplastic anaemia and agranulocytosis have occurred with Carbamazepine. A baseline blood count is recommended, and patients should promptly report persistent fever, sore throat, unusual infections, easy bruising, or unexplained bleeding.

Low sodium levels

Carbamazepine can cause hyponatremia, sometimes related to SIADH. Warning symptoms may include:

• Headache
• Confusion
• Weakness
• Unsteadiness
• Difficulty concentrating
• Increased seizure frequency

Older adults and patients taking diuretics may be at greater risk.

Common side effects of Eplic Syrup 120ML

Commonly reported effects of Carbamazepine include:

• Dizziness
• Drowsiness
• Unsteadiness
• Nausea
• Vomiting

These effects may be more noticeable when treatment is first started or when the dosage is increased.

Seek urgent medical attention for

• Severe or spreading skin rash
• Blisters or peeling skin
• Fever with sore throat
• Unusual bruising or bleeding
• Yellowing of the eyes or skin
• Severe confusion
• Marked weakness
• Facial or throat swelling
• Difficulty breathing
• Severe worsening of seizures
• Thoughts of self-harm or major unusual changes in mood or behaviour

Pregnancy and Breastfeeding

Carbamazepine can cause fetal harm and has been associated with congenital abnormalities, including neural-tube defects such as spina bifida. Women who are pregnant, planning pregnancy, or could become pregnant should discuss the benefits and risks with their neurologist or physician.

A patient with epilepsy should not suddenly stop Eplic Syrup 120ML after discovering a pregnancy, because uncontrolled seizures and abrupt antiepileptic withdrawal can also pose serious risks. The treating doctor should urgently review therapy.

Carbamazepine and its active metabolite pass into breast milk. Breastfeeding decisions should therefore be discussed with the treating physician.

Important Drug and Food Interactions

Eplic Syrup 120ML can interact with many medicines because Carbamazepine strongly affects liver enzymes.

Tell the physician about all medicines, supplements, and herbal products being used. Important interactions can occur with some:

• Other antiepileptic medicines
• Antibiotics such as clarithromycin or erythromycin
• Antifungal medicines
• Certain antidepressants and psychiatric medicines
• Heart and blood-pressure medicines
• Rifampicin
• Warfarin and other medicines whose blood levels can be altered
• Other liquid medicines

Grapefruit juice may increase Carbamazepine levels and should generally be avoided unless the physician advises otherwise. Alcohol can increase drowsiness and sedation.

Reference prescribing information also advises that Carbamazepine oral suspension should not be administered simultaneously with other liquid medicinal products or diluents because physical interactions have been observed with some liquid medicines.

Storage Instructions

• Store Eplic Syrup 120ML according to the instructions printed on the local product packaging.
• Keep the bottle tightly closed.
• Protect it from excessive heat and direct light.
• Keep the medicine out of the sight and reach of children.
• Do not use after the stated expiry date.

Reference Carbamazepine 100mg/5ml suspension should not be stored above 30°C.

Frequently Asked Questions (FAQs)

What is the price of Eplic Syrup 120ML in Pakistan?

Price in Pakistan: PKR 195. The final retail price may vary slightly between pharmacies and locations.

What are the uses of Eplic Syrup 120ML?

Eplic Syrup 120ML is used under medical supervision for certain forms of epilepsy and seizures and for pain associated with true trigeminal neuralgia. It is not appropriate for every seizure type.

Is Eplic Syrup 120ML safe for children with epilepsy?

Eplic Syrup 120ML may be prescribed to children with appropriate seizure disorders, but the dose must be selected according to age, body weight, seizure type, and treatment response by a doctor.

Can Eplic Syrup 120ML be stopped when seizures are controlled?

No, Eplic Syrup 120ML should not be stopped suddenly. Abrupt Carbamazepine withdrawal can cause seizures to return or worsen, so any dose reduction must be supervised by a physician.

Pakistan Medicine-Safety Information

Eplic Syrup 120ML is a prescription-only medicine and should be used only on a doctor’s recommendation. Patients and healthcare professionals in Pakistan can obtain medicine-regulation information from the Drug Regulatory Authority of Pakistan and report suspected adverse reactions through its pharmacovigilance system. And we also have Eplic Carbamazepine (200MG) Tablet.

Drug Regulatory Authority of Pakistan (DRAP)
National Institutes of Health Pakistan (NIH)

Medical Disclaimer

This information is provided for patient education and product-information purposes only. It does not replace diagnosis, neurological assessment, blood testing, dosage selection, or follow-up by a qualified healthcare professional.

Eplic Syrup 120ML must be used only on the prescription and recommendation of a registered medical practitioner. Never start, stop, increase, or reduce Carbamazepine treatment without consulting the treating doctor.