Co-Vmed 5mg/160mg/12.5mg Tablets

Description

Product Information

• Product name: Co-Vmed 5mg/160mg/12.5mg
• Focus keyword: Co-Vmed
• Generic name: Amlodipine BP/Valsartan USP/Hydrochlorothiazide USP
• Dosage form: Tablet
• Product type: Triple-combination antihypertensive
• Therapeutic classes: Calcium Channel Blocker + Angiotensin II Receptor Blocker + Thiazide Diuretic
• Prescription status: Prescription medicine
• Price: PKR 630

Composition of Co-Vmed

Each Co-Vmed tablet contains:

• Amlodipine BP 5mg, provided as Amlodipine Besylate
• Valsartan USP 160mg
• Hydrochlorothiazide USP 12.5mg

This strength provides three blood-pressure medicines in one tablet. The 5mg/160mg/12.5mg combination is a recognized strength of Amlodipine, Valsartan, and Hydrochlorothiazide tablets.

What is Co-Vmed?

Co-Vmed is a fixed-dose combination medicine used for the treatment of hypertension, commonly called high blood pressure. It is generally considered for adults who need stronger blood-pressure control than two antihypertensive medicines can provide.

Co-Vmed contains three active ingredients:

1. Amlodipine, a dihydropyridine calcium channel blocker
2. Valsartan, an angiotensin II receptor blocker
3. Hydrochlorothiazide, a thiazide diuretic or “water tablet”

Comparable triple-combination products are used as add-on, switch, or replacement therapy in patients whose blood pressure is not adequately controlled with two of these medicine classes. They are not generally intended as the initial treatment for newly diagnosed hypertension.

How Does Co-Vmed Work?

Co-Vmed lowers blood pressure through three complementary mechanisms.

Amlodipine 5mg

Amlodipine helps relax and widen blood vessels by reducing calcium entry into the muscle cells of the vessel walls. This decreases resistance to blood flow.

Valsartan 160mg

Valsartan blocks the effects of angiotensin II, a natural substance that can cause blood vessels to tighten. Blocking this action allows blood vessels to remain more relaxed.

Hydrochlorothiazide 12.5mg

Hydrochlorothiazide increases the removal of excess sodium and water through urine. Reducing excess fluid can decrease circulating blood volume and help lower blood pressure.

Through these combined actions, Co-Vmed may provide greater blood-pressure reduction than a dual combination in patients who require triple therapy.

Uses & Benefits of Co-Vmed

Co-Vmed is used for the treatment and ongoing management of high blood pressure in adults.

Potential uses and benefits include:

• Treatment of hypertension
• Management of uncontrolled high blood pressure
• Triple therapy when two antihypertensive medicines are insufficient
• Replacement of separately titrated Amlodipine, Valsartan, and Hydrochlorothiazide
• Relaxation of narrowed blood vessels
• Reduction of excess sodium and fluid
• Improved convenience through three medicines in one tablet
• Support for more consistent once-daily treatment

Lowering elevated blood pressure is associated with a reduced risk of serious cardiovascular complications, particularly stroke and heart attack. However, specific percentage reductions in cardiovascular events should not be attributed to Co-Vmed unless supported by product-specific clinical evidence.

Who Should Use This? (Target Audience)

Co-Vmed is intended for adult patients with high blood pressure who require triple antihypertensive therapy.

A physician may consider Co-Vmed for:

• Adults whose blood pressure remains uncontrolled with two medicines
• Patients already taking a calcium channel blocker, ARB, and diuretic separately
• Patients requiring Amlodipine, Valsartan, and Hydrochlorothiazide in one tablet
• Adults with moderate or difficult-to-control hypertension
• Patients for whom a physician considers once-daily triple therapy appropriate

Co-Vmed should not be selected only because a single blood-pressure reading is high. The physician should consider repeated readings, previous treatment response, kidney function, electrolyte levels, other medical conditions, and current medicines.

How to Use / Dosage

Use Co-Vmed exactly as prescribed by the treating physician.

General dosage guidelines

• Co-Vmed is typically taken once daily.
• It may be taken with or without food.
• Take the tablet at approximately the same time each day.
• Swallow the tablet with water.
• Do not take more than the prescribed amount.
• Do not change the strength without medical advice.
• Do not stop treatment simply because your blood-pressure reading becomes normal.

Comparable Amlodipine, Valsartan, and Hydrochlorothiazide combinations are dosed once daily. Treatment adjustment should be based on blood-pressure response, tolerance, kidney function, and laboratory results.

What should you do if you miss a dose?

Take the missed dose when you remember. When it is almost time for the next dose, skip the missed tablet and continue with the usual schedule.

Do not take two Co-Vmed tablets together to compensate for a missed dose.

Price in Pakistan

Price in Pakistan: PKR 630

The final Co-Vmed retail price may vary slightly between pharmacies, cities, and available stock. Purchase prescription medicines from a licensed and reliable pharmacy.

Precautions & Side Effects

Before taking Co-Vmed, tell your physician about your complete medical history and all prescription medicines, non-prescription medicines, supplements, and herbal products you use.

Important precautions before using Co-Vmed

Inform your doctor if you:

• Have kidney disease or reduced kidney function
• Have liver disease
• Have heart failure or another serious heart condition
• Have low blood pressure
• Have reduced or no urine output
• Are dehydrated due to vomiting, diarrhoea, or excessive sweating
• Follow a strict low-salt diet
• Have diabetes
• Have gout or elevated uric acid
• Have lupus
• Have high or low potassium levels
• Have low sodium levels
• Have a history of gallstones
• Have an allergy to sulfonamide-derived medicines
• Are scheduled for surgery or dialysis

Kidney function, blood pressure, and electrolyte levels may require monitoring because Valsartan and Hydrochlorothiazide can affect renal function, potassium, sodium, and fluid balance.

Who should not use Co-Vmed?

Co-Vmed should not be used by patients with:

• Anuria, meaning no urine output
• Known hypersensitivity to any active ingredient
• Hypersensitivity to sulfonamide-derived medicines

Aliskiren must not be used with this combination in patients who have diabetes.

Important Medicine Interactions

Tell your physician if you take:

• Aliskiren
• Other antihypertensive medicines
• ACE inhibitors or other ARBs
• Additional diuretics
• Potassium supplements
• Potassium-containing salt substitutes
• Lithium
• Non-steroidal anti-inflammatory drugs, such as ibuprofen or diclofenac
• Medicines that affect kidney function
• Medicines used for diabetes
• Other medicines that may lower blood pressure

These combinations may increase the risk of low blood pressure, kidney impairment, electrolyte changes, or other adverse effects. Do not start a new medicine or supplement while taking Co-Vmed without consulting a doctor or pharmacist.

Storage Instructions

• Store Co-Vmed at controlled room temperature.
• Protect the tablets from moisture.
• Keep Co-Vmed in its original packaging.
• Protect it from excessive heat and direct sunlight.
• Keep the medicine out of the sight and reach of children.
• Do not use tablets after the printed expiry date.

Comparable products are stored at 20°C to 25°C, with permitted excursions between 15°C and 30°C. The storage directions printed on the approved Co-Vmed packaging should take priority.

Frequently Asked Questions (FAQs)

What is the price of Co-Vmed in Pakistan?

The listed Co-Vmed price in Pakistan is PKR 630. The final retail amount may vary according to the pharmacy, location, and stock availability.

What are the uses of Co-Vmed?

Co-Vmed is used to manage high blood pressure in adults who require triple antihypertensive therapy. It may be prescribed when treatment with two blood-pressure medicines does not provide adequate control.

Is Co-Vmed safe for high blood pressure patients?

Co-Vmed may be appropriate for selected adult hypertension patients when prescribed by a physician. Kidney function, electrolyte levels, pregnancy status, medical history, and medicine interactions should be assessed before treatment.

What is the composition of Co-Vmed?

Each Co-Vmed tablet contains Amlodipine 5mg, Valsartan 160mg, and Hydrochlorothiazide 12.5mg.

Can Co-Vmed be taken with food?

Yes. Co-Vmed is generally taken once daily with or without food. Follow the exact instructions provided by the treating physician.

Is Co-Vmed a water tablet?

Co-Vmed contains Hydrochlorothiazide, which is a thiazide diuretic or water tablet. It also contains Amlodipine and Valsartan, so it is a triple-combination blood-pressure medicine rather than only a diuretic.

Can pregnant women use Co-Vmed?

No. Co-Vmed contains Valsartan, which may cause serious fetal harm. Pregnancy during treatment requires immediate contact with the treating physician.

Can Co-Vmed be stopped when blood pressure becomes normal?

Do not stop Co-Vmed without medical advice. A normal reading may indicate that the treatment is controlling the blood pressure successfully.

Pakistan Medicine-Safety Information

Patients and healthcare professionals can report suspected adverse effects through the DRAP adverse-event reporting system. DRAP provides an official Med Vigilance electronic reporting channel for adverse events in Pakistan.

Hypertension is included among the major non-communicable diseases monitored in Pakistan. Additional local public-health information is available from the Health Research Institute, National Institutes of Health Pakistan.

Medical Disclaimer

This product information is provided for educational purposes only and does not replace medical advice, diagnosis, monitoring, or treatment by a qualified healthcare professional.

Co-Vmed is a prescription medicine. Use Co-Vmed only on the prescription of a registered medical practitioner. Do not start, stop, or change the dosage without consulting your physician.