Description
What is Clipin Tablets 100mg?
Clipin Tablets 100mg contains clozapine, an atypical antipsychotic medicine used for difficult-to-treat schizophrenia.
Clozapine is different from many routine antipsychotic medicines because it is usually reserved for patients whose symptoms have not responded adequately to standard treatment. FDA prescribing information describes clozapine for severely ill patients with schizophrenia who have failed to respond adequately to standard antipsychotic therapy.
The manufacturer’s Pakistan product information also lists Clipin for treatment-resistant schizophrenia and for reducing recurrent suicidal behaviour in selected patients with schizophrenia or schizoaffective disorder. Cell Laboratories Pvt Ltd.
Product Information
- Product Name: Clipin Tablets 100mg
- Generic Name: Clozapine USP
- Strength: 100 mg per tablet
- Dosage Form: Oral tablet
- Drug Class: Atypical antipsychotic
- Pack Size: 50 tablets
- Manufacturer: Cell Laboratories (Pvt.) Ltd.
- Main Use: Treatment-resistant schizophrenia
Uses & Benefits of Clipin Tablets 100mg
Clipin Tablets 100mg may be prescribed by a psychiatrist when schizophrenia remains difficult to control despite appropriate use of other antipsychotic medicines.
Important uses include:
- Treatment-resistant schizophrenia: May help patients whose symptoms have not improved sufficiently with standard antipsychotic treatments.
- Hallucinations: May help reduce hearing or seeing things that are not present.
- Delusions: Can help reduce strongly held false beliefs associated with psychosis.
- Disorganized thinking: May help improve thought organization and communication.
- Severe psychotic symptoms: Can be useful in patients who continue to experience significant symptoms despite previous treatment.
- Reduction of recurrent suicidal behaviour: Clozapine is also indicated for selected patients with schizophrenia or schizoaffective disorder who remain at chronic risk of suicidal behaviour.
For Pakistani patients, Clipin Tablets 100mg should be considered a specialist psychiatric medicine rather than a routine first-line treatment for newly diagnosed schizophrenia.
Who Should Use This? (Target Audience)
Clipin Tablets 100mg is mainly intended for adults in Pakistan with treatment-resistant schizophrenia who are being managed by a psychiatrist.
It may be suitable for:
- Adults whose schizophrenia has not responded adequately to other antipsychotics
- Patients who experienced unacceptable side effects with alternative treatment options
- Selected adults with schizophrenia or schizoaffective disorder who have recurrent suicidal behaviour
- Patients already established on clozapine treatment who require a 100 mg tablet strength as part of their prescribed daily dose
Clipin Tablets 100mg should not be started without specialist medical supervision.
Before prescribing clozapine, the psychiatrist normally reviews previous treatment, physical health, current medicines and blood counts.
How to Use / Dosage
Clipin Tablets 100mg should be taken exactly as prescribed by the treating psychiatrist.
Clozapine treatment is normally started at a much lower dose than 100 mg. Current FDA prescribing information recommends a starting dose of 12.5 mg once or twice daily, followed by careful increases if treatment is tolerated. The dose may be gradually increased toward the patient’s required maintenance dose.
This means Clipin Tablets 100mg is generally not used as the first tablet strength when clozapine treatment is first started.
Patients should:
- Take Clipin Tablets 100mg at the prescribed time.
- Take it with or without food unless otherwise advised.
- Never increase the dose themselves.
- Never take extra tablets to make up for a missed dose.
- Tell the psychiatrist if several doses have been missed.
- Never restart the previous full dose after an interruption without medical advice.
Clozapine often needs to be restarted at a lower dose after a significant treatment interruption because restarting too quickly can cause dangerous low blood pressure, slow heart rate or fainting.
Why Does Clipin Tablets 100mg Need Blood Tests?
Regular blood monitoring is especially important with Clipin Tablets 100mg because clozapine can cause severe neutropenia.
Neutrophils are white blood cells that help the body fight infections. If their number becomes very low, the risk of serious infection increases.
Current FDA labeling recommends obtaining an absolute neutrophil count (ANC) before treatment and continuing ANC monitoring during clozapine therapy. Treatment initiation is generally not recommended when baseline ANC is below 1,500/µL in the general population, with different considerations for patients with documented Duffy-null-associated neutrophil counts.
The FDA removed the mandatory U.S. Clozapine REMS participation requirement in 2025, but it continues to recommend ANC monitoring because the risk of severe neutropenia remains.
For patients taking Clipin Tablets 100mg in Pakistan, blood-test frequency and treatment decisions should follow the psychiatrist’s instructions and locally applicable clinical practice.
Price in Pakistan
Price in Pakistan: PKR 2,500.00
The price of Clipin Tablets 100mg is PKR 2,500.00 for 50 tablets. The manufacturer’s current online listing also shows Clipin at PKR 2,500. Cell Laboratories Pvt Ltd.
Pharmacy prices may change according to location, stock availability or manufacturer price revisions.
Precautions & Side Effects
Important Precautions
Before using Clipin Tablets 100mg, tell the psychiatrist if the patient has:
- A history of low white blood cell counts
- Heart disease
- Previous myocarditis or cardiomyopathy
- Epilepsy or seizures
- Low blood pressure or fainting
- Severe or long-lasting constipation
- Diabetes
- Liver or kidney disease
- Difficulty swallowing
- Pregnancy or breastfeeding
- Allergies to clozapine
- Other medicines that affect the brain, heart or blood cells
Smoking status is also important. Starting or stopping cigarette smoking can alter clozapine exposure, so patients should tell their psychiatrist if their smoking habits change.
Medicine Safety in Pakistan
Patients using Clipin Tablets 100mg in Pakistan should maintain regular follow-up with their psychiatrist and complete all requested laboratory tests.
The Drug Regulatory Authority of Pakistan (DRAP) operates the National Pharmacovigilance Centre for monitoring the safety of therapeutic products in Pakistan. Patients, caregivers and healthcare professionals can report suspected adverse events directly to DRAP.
Frequently Asked Questions (FAQs)
What is the price of Clipin Tablets 100mg in Pakistan?
The listed Clipin Tablets 100mg price in Pakistan is PKR 2,500.00 for 50 tablets. Retail prices can vary between pharmacies. Cell Laboratories Pvt Ltd.
What are the uses of Clipin Tablets 100mg?
Clipin Tablets 100mg is mainly used for treatment-resistant schizophrenia. Clozapine can also be used to reduce recurrent suicidal behaviour in selected patients with schizophrenia or schizoaffective disorder.
Is Clipin Tablets 100mg used for treatment-resistant schizophrenia?
Yes. Clipin Tablets 100mg contains clozapine, which is specifically used when standard antipsychotic treatment has not adequately controlled schizophrenia symptoms.
Does Clipin Tablets 100mg require regular blood tests?
Yes. Clipin Tablets 100mg requires ANC monitoring because clozapine can reduce infection-fighting neutrophils. The psychiatrist decides the appropriate testing schedule for each patient.
Important Medical Notice
Clipin Tablets 100mg is a prescription psychiatric medicine and must be used under specialist medical supervision.
This information is intended for patients and caregivers in Pakistan and does not replace a psychiatrist’s diagnosis, prescription or monitoring plan. FDA references above relate to clozapine as the active medicine, while DRAP sources provide Pakistan-specific medicine-safety and adverse-event reporting information.
Do not start, stop, restart, increase or reduce Clipin Tablets 100mg without instructions from the treating psychiatrist.
