Description
What is Clipin Tablets 25mg?
Clipin Tablets 25mg contains clozapine, an atypical antipsychotic medicine used for certain severe psychiatric conditions.
Unlike medicines commonly used as first treatment for schizophrenia, clozapine is generally reserved for patients who have not responded adequately to standard antipsychotic treatment. FDA prescribing information describes clozapine as a treatment option for severely ill patients with schizophrenia who continue to have symptoms despite appropriate treatment with other antipsychotic medicines.
Product Information
- Product name: Clipin Tablets 25mg
- Generic name: Clozapine USP
- Strength: 25 mg per tablet
- Dosage form: Oral tablet
- Drug class: Atypical antipsychotic
- Pack size: 50 tablets
- Main use: Treatment-resistant schizophrenia
- Manufacturer: Cell Laboratories (Pvt.) Ltd.
Uses & Benefits of Clipin Tablets 25mg
Clipin Tablets 25mg is mainly intended for patients who need specialist treatment for schizophrenia that has not improved enough with other antipsychotics.
Potential uses include:
- Treatment-resistant schizophrenia: Clipin Tablets 25mg may help when adequate trials of standard antipsychotic medicines have not controlled symptoms.
- Hallucinations and delusions: Clozapine may help reduce hearing, seeing, or strongly believing things that are not based in reality.
- Disorganized thinking: Treatment may help some patients think and communicate more clearly.
- Severe behavioural symptoms: It may help reduce severe agitation or other symptoms related to schizophrenia.
- Persistent positive and negative symptoms: Clozapine may improve symptoms in some patients who have responded poorly to other treatments.
- Reduction of recurrent suicidal behaviour: Clozapine is FDA-indicated to reduce recurrent suicidal behaviour in patients with schizophrenia or schizoaffective disorder who are considered at ongoing risk.
Clipin Tablets 25mg is not normally a first-choice medicine for newly diagnosed schizophrenia because clozapine requires careful safety monitoring.
Who Should Use This?
Clipin Tablets 25mg is mainly intended for adults with treatment-resistant schizophrenia under specialist psychiatric care.
It may also be considered for selected patients with schizophrenia or schizoaffective disorder who have a significant ongoing risk of suicidal behaviour.
A psychiatrist should review the patient’s previous antipsychotic treatments, symptoms, physical health, current medicines, and blood results before starting Clipin Tablets 25mg.
This medicine should not be started simply for mild anxiety, sleep problems, routine depression, or ordinary behavioural difficulties.
How to Use / Dosage
Clipin Tablets 25mg must be started and adjusted carefully by a psychiatrist.
FDA prescribing information recommends starting clozapine at a low dose of 12.5 mg once or twice daily. If tolerated, the daily dose may be gradually increased by 25–50 mg per day, with further adjustments according to the patient’s response and side effects.
A typical treatment plan may gradually move toward a total daily dose of approximately 300–450 mg, but the correct dose can be considerably different for individual patients.
Important Dosing Advice
Patients using Clipin Tablets 25mg should:
- Take it exactly as prescribed.
- Take doses at the times advised by the psychiatrist.
- Not increase the dose themselves.
- Not double a forgotten dose.
- Tell the doctor if treatment has been interrupted.
- Not restart their previous full dose after several missed doses without medical advice.
Restarting clozapine after an interruption may require a much lower dose because rapid re-exposure can increase the risk of severe low blood pressure, slow heart rate, fainting, or other cardiovascular effects. FDA labeling therefore requires careful re-titration after certain treatment interruptions.
Blood Tests and ANC Monitoring
Regular blood monitoring is one of the most important parts of treatment with Clipin Tablets 25mg.
Clozapine can cause severe neutropenia, meaning a dangerous reduction in infection-fighting white blood cells. This can lead to serious or potentially fatal infections.
Current FDA labeling recommends measuring the absolute neutrophil count (ANC) before starting clozapine. Starting treatment is generally not recommended if the baseline ANC is below 1,500/µL in the general population or below 1,000/µL in people with documented benign ethnic neutropenia/Duffy-null associated neutrophil count.
Patients in Pakistan should follow the laboratory-monitoring schedule given by their psychiatrist and local healthcare facility.
Price in Pakistan
Price in Pakistan: PKR 1,250.00
The provided price of Clipin Tablets 25mg is PKR 1,250.00 for 50 tablets.
The final retail price may vary between pharmacies, cities, stock batches, or future manufacturer price revisions.
Precautions & Side Effects
Clipin Tablets 25mg requires closer monitoring than many other antipsychotic medicines because some clozapine reactions can be serious.
Important Precautions
Tell the psychiatrist before using Clipin Tablets 25mg if the patient has:
- A history of low white blood cell counts
- Heart disease
- Previous myocarditis or cardiomyopathy
- Seizures or epilepsy
- Low blood pressure or frequent fainting
- Severe constipation or bowel problems
- Diabetes
- Liver or kidney disease
- Difficulty swallowing
- Pregnancy or breastfeeding
- Other medicines that can affect blood counts, heart function, or the nervous system
Patients should also tell their psychiatrist if they start or stop smoking, because cigarette smoking can affect how the body processes clozapine and may change the amount of medicine in the blood.
Common Side Effects
Possible side effects of Clipin Tablets 25mg include:
- Sleepiness
- Dizziness
- Increased saliva or drooling
- Constipation
- Headache
- Fast heartbeat
- Weight gain
- Increased appetite
- Tiredness
- Low blood pressure, particularly when standing
Frequently Asked Questions (FAQs)
What is the price of Clipin Tablets 25mg in Pakistan?
The listed price of Clipin Tablets 25mg in Pakistan is PKR 1,250.00 for 50 tablets. Pharmacy prices may vary.
What are the uses of Clipin Tablets 25mg?
Clipin Tablets 25mg contains clozapine and is mainly used for treatment-resistant schizophrenia. Clozapine may also reduce recurrent suicidal behaviour in selected patients with schizophrenia or schizoaffective disorder.
Is Clipin Tablets 25mg used for treatment-resistant schizophrenia?
Yes. Clipin Tablets 25mg contains clozapine, which is specifically used for severely ill patients with schizophrenia who have not responded adequately to standard antipsychotic treatment.
Does Clipin Tablets 25mg require blood tests?
Yes. Patients taking Clipin Tablets 25mg require ANC blood monitoring because clozapine can cause severe neutropenia. The treating psychiatrist determines how often testing is required.
Important Medical Notice
Clipin Tablets 25mg is a prescription antipsychotic medicine requiring specialist supervision. It should not be started, stopped, restarted after an interruption, or adjusted without instructions from a psychiatrist or other appropriately qualified physician.
FDA information in this description relates to clozapine as the active medicine, while DRAP references provide Pakistan-specific pharmacovigilance and adverse-event reporting information. Patients should follow the locally registered product information and their psychiatrist’s instructions.
